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About Our Research

The First Cleared by the FDA

In 1994, the FDA cleared the Anodyne Therapy System for human use. This was the first product using infrared LEDs cleared to increase circulation and relieve pain. Over 20 years later, Anodyne continues its market leadership in evidence-based light therapy products.


Anodyne is Proven

25 studies published since 1999 in noted medical journals show the pain relieving benefits of the Anodyne Therapy Systems in nearly 5,000 patients. Anodyne studies are published in medical journals such as Diabetes Care, Practical Pain Management, Age and Ageing, and Endocrine Practice. Most of the studies about Anodyne and pain relief relate to foot and leg pain, knee pain and lower back pain.

Don't Be Fooled

All light therapy products are not alike even if they have all been cleared by the FDA. Unlike Anodyne, most light therapy products have no published evidence that they work. They rely solely on testimonials, general scientific evidence related to light therapy in general or studies conducted with other peoples’ products.


Anodyne Therapy is MIRE

Throughout our studies, the acronym MIRE is referenced. MIRE is Monochromatic Infrared Energy and is a trademark of Anodyne Therapy technology specifically.

Published Clinical Data

Foot Pain Studies

This is the most studied topic for the use of Anodyne, which includes 15 published studies that detail the benefits obtained by more than 4,000 patients. Looking at these studies collectively, the vast majority of patients responded to treatments that included Anodyne and that the average pain relief was more than 50%. Publications include:

  • Alan B. Kochman, MSPT, Dale H. Carnegie, DPM, Thomas J. Burke, PhD. J Am Podiatr Med Assoc 2002
  • Joseph Prendergast, MD, Galdina Miranda, MA, Manuel Sanchez, MA.  24 ENDOCRINE PRACTICE Vol 10 No. 1 January/February 2004
  • Alan B. Kochman, MSPT J. Geriatr Phys Ther. 2004
  • David R. Leonard, MD, FACE, Hamed Farooqi, MD, FACE, Sara Myers, RN
    Diabetes Care 27, 2004
  • Salvatore L. DeLellis, DPM, Dale H. Carnegie, DPM, Thomas J. Burke, PhD. J Am Podiatr Med Assoc 2005
  • Lawrence B. Harkless, DPM, Salvatore DeLellis, DPM, Dale H. Carnegie, DPM, Thomas J. Burke, PhD. Journal of Diabetes and Its Complications. 2006
  • Wendy Volkert, MSPT, Ahmed Hassan, PT, MS, Mohamed A. Hassan, PT, MHS, Vicki L. Smock, PT, Justin P. Connor, PT, Becky McFee, PT, Shayne K. Ferguson, PT, MHS, PhD, GCS, CWS, Thomas J. Burke, PhD. Physical & Occupational Therapy in Geriatrics, Vol. 24(2) 2006
  • Mark W. Powell, Dale H. Carnegie, Thomas J. Burke. Age and Ageing 2006
  • Thomas J. Burke, PhD. Practical PAIN MANAGEMENT, July/August 2007
  • Palanghi F., DeBellis A., Gioffredi M., Gori R., Picciafouchi R., Martini N., Anichini R. European Association for the Study of Diabetes 2009
  • Stanley Paul, Yuanlong Liu, Robert McAlister. Indian Journal of Physiotherapy and Occupational Therapy. January-March 2010
  • Tarek A. Ammar, PT, PhD. International Scholarly Research Network Rehabilitation ISRN Rehabilitation, 2012
  • Wendy M. Ferx, MS, PT; Meredith R. Hall, DPT. FEDERAL PRACTITIONER, September 2015

Knee & Back Pain Studies

The authors of the following published studies describe pain relief obtained with the Anodyne Therapy System compared to conventional treatments. Looking at these studies collectively, the vast majority of patients responded to treatments that included Anodyne and that the average pain relief was more than 50%.

  • Tarek A. Anmar, PT, PhD. Bull. Fac. Ph.Th.Cairo Univ., Vol. 15, No. (2) Jul. 2010 (Knee pain relief)
  • Tarek Anmar, PT, PhD. Lasers Med Sci 2014; 5(4):176-82 (Knee Pain Relief)
  • Ru-Lan Hsieh & Wen-Chung Lee. Lasers Med Sci DOI 10.1007/s10103-013-1378-2 (Back pain relief)
  • Tarek Abdel, Rahman Ali Anmar. Journal of Lasers in Medical Science, 2015, 6(4): 157-161
To request published Anodyne studies, click here

Monochromatic Infrared Photo Energy in Diabetic Peripheral Neuropathy

Patients treated with Anodyne Therapy obtained more pain relief than those who were not treated with Anodyne.

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Infrared Photo Energy May Reduce Neuropathic Pain

Patients who received Anodyne Therapy treatments experienced a 64% reduction in pain.

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Effectiveness of Monochromatic Infrared Photo Energy and PT for Peripheral Neuropathy

More than 90% of patients obtained significant foot pain relief.

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Symptomatic Reversal of Peripheral Neuropathy in Patients with Diabetes

94% of patients reported significant relief from their pain/discomforting foot sensations.

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Improvement of Sensory Impairment in Patients with Peripheral Neuropathy

96% of patients obtained relief from pain/discomforting foot sensations.

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Restoration of Sensation, Reduced Pain, and Improved Balance in Subjects With Diabetic Peripheral Neuropathy

Patients obtained significant pain relief after both 2 and 4 weeks of treatment.

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Reversal of Diabetic Peripheral Neuropathy with MIRE

87% of patients reported continuing foot pain relief after 9 months!

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A Combined Treatment Protocol for Patients With Diabetic Peripheral Neuropathy

Following completion of the clinic-based protocol, the study evaluated the real-life results of ongoing unsupervised home use of Anodyne Therapy.

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The Efficacy of Monochromatic Infrared Photo-Thermal Energy Therapy in Rehabilitation: A Pilot Study report

Patients receiving treatments with Anodyne Therapy showed significant pain relief, improved feeling, and better balance.

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Near-Infrared Photo Energy Therapy (Anodyne) could Reduce Diabetic Peripheral Neuropathic Pain

More than 88% of patients receiving treatments with Anodyne Therapy and physical therapy obtained significant pain relief and used less pain relieving pain medications.

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Diabetes Care

Volume 27(1), January 2004

Joslin Center for Diabetes at Morton Plant Hospital – Prospective, Randomized, Double Blind, Placebo Controlled
The results of the study demonstrate that treatments with near-infrared photo energy, MIRE™ delivered in the manner specified in the study protocol resulted in a significant reduction in lower extremity pain.


Diabetes and Its Complications

Volume 20(2), 2006

Multiple Site Retrospective Chart Review based on Prospective, Repeated Measures Analysis
MIRE appears to be associated with significant clinical improvement in foot sensation and, simultaneously, a reduction in neuropathic pain in a large cohort of primarily Medicare aged, community-dwelling patients, initially diagnosed with PN. The quality of life associated with these two outcomes cannot be underappreciated.


Physical & Occupational Therapy in Geriatrics

Volume 24(2), 2006

This was a retrospective Chart Review in seven facilities and was based on Prospective, Repeated Measures Analysis
Compared with the literature, preliminary findings suggest that MIRE™ plus manual physical therapy improves pain, balance, and sensation symptoms in patients with peripheral neuropathy, at least temporarily.


Age and Ageing

Volume 35(1), 2006

Multi-Site Retrospective Chart Review and Patient Questionnaire
The medical records indicated that 220 out of 252 patients (87%, p< 0.0001) obtained substantial reduction in lower extremity pain. When patients have continuing access to MIRE™ in their homes following clinical treatment, there is a significant reduction in pain.


Practical Pain Management

Volume 7(6), 2007

Multiple Site Retrospective Chart Review based on Prospective, Repeated Measures Analysis in combination with patient phone survey on prescription pain medication use.
MIRE, when administered as part of a physical therapy care plan prescribed by a physician, is associated with substantial lower extremity pain relief and the pain-relieving effects of Anodyne® Therapy/MIRE™ appear to be independent of pain medication use.

Increases in Circulation

Blood Flow Laser Doppler Imaging

Circulation increases were measured by a Moor Scanning Laser Doppler after a 20 – 30 minute Anodyne Therapy treatment. Brighter areas in the images below indicate increased circulation.

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UP TO 3200% INCREASE
UP TO 2000% INCREASE
UP TO 1300% INCREASE

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